Comparative histopathology of the lymph nodes, spleen, liver and kidney in experimental ovine trypanosomosis.
نویسندگان
چکیده
The infection of Yankassa rams with three important trypanosome species affecting livestock, namely, Trypanosoma congolense, T. vivax and T. bruceiproduced both acute and chronic fatal conditions. Chronic infections were induced in the three infections by the application of subcurative doses of diaminazene aceturate (Berenil). Pathological changes in the infected animals included splenomegaly and hepatomegaly which were more pronounced in acute than in chronic T. congolense infection. However, these changes were more severe in chronic than in acute T. vivax infection. While splenomegaly was more pronounced in chronic T. bruceiinfection than in acute, hepatomegaly and lymphadenopathy were more severe in acute than in the chronic condition. The increases in size of the spleen, lymph nodes and liver were associated with congestion, increases in cell density related to increased immunological reactions in the spleen and lymph nodes as well as increase in numbers, size and activity of the phagocytic cells in these organs.
منابع مشابه
بررسی تاثیر فرآورده دارویی MS14 بر وزن، اندیکس طحال و ساختاربافتهای کلیه، کبد، طحال، ریه، گره لنفی و مغز استخوان موش
Abstract Background: MS14 is an Herbal-marine preparation that has been used in experimental studies for the management of Multiple sclerosis, (MS). In this study the effect of MS14 on body weight, spleen index and the histological picture of various organs was evaluated. Methods: Female Balb/C mice of 6-8 weeks age were divided into control and test groups. MS14 was orally administrated ...
متن کاملA comparison of virulence of intraperitoneal infection of Burkholderia mallei strains in guinea-pigs
Male guinea pigs show high susceptibility to Burkholderia mallei and have been used as animal models in glanders studies. The purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. We present here the histological changes and bacterial isolation that develop over time in guinea pigs inoculated intraperitoneally (IP) with two strain of B. mallei. Ten male guinea ...
متن کاملRare ocular and skin lesions of Marginal Zone Lymphoma detected by 18F-FDG PET/CT
We report a case of a 75-year old man that came at hematologist’s attention for lymphoma evaluation due to axillary lymph node enlargement and fever. Thorax, abdomen and pelvis Contrast-Enhanced Computed Tomography (CECT) showed lymph nodes, spleen and liver lesions. Axillary lymph node biopsy was performed and the diagnosis of marginal zone lymphoma (MZL) at stage IV was postulated, then the p...
متن کاملEffects of mycophenolic acid (MPA) treatment on expression of Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) mRNA in adult sheep tissues.
AIM To quantify the expression of Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) mRNA under a long-term influence of mycotoxin mycophenolic acid (MPA), which is used in human transplantation medicine due to its immunosuppressive properties and is a common contaminant in silage. METHOD We applied 300 mg MPA/day in nine sheep for nine weeks and compared them with untreated anim...
متن کاملControl of Experimental Trypanosoma brucei Infections Occurs Independently of Lymphotoxin- Induction
Trypanosome infections are marked by severe pathological features, including anemia, splenomegaly, and suppression of T-cell proliferation. We have used lymphotoxin-deficient (LT/ ) mice, as well as LT– tumor necrosis factor-double-deficient (LT/ TNF / ) mice, to analyze the contributions of these related cytokines in both induction of trypanosomosis-associated immunopathology and infection con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Onderstepoort journal of veterinary research
دوره 76 4 شماره
صفحات -
تاریخ انتشار 2009